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Combination of active components of Xiexin decoction ameliorates renal fibrosis through the inhibition of NF-κB and TGF-β1/Smad pathways in db/db diabetic mice.

Please log in. Inflammation and Oxidative Stress in Chronic Kidney Disease-Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites. Clipboard, Search History, and several other advanced features are temporarily unavailable. Therefore, 7 compounds were identified as major antioxidant biomarkers for quality control of C. tinctoria. New insights into established therapeutic paradigms and novel molecular targets.

Alrawahi AH, Rizvi SG, Al-Riyami D, Al-Anqoodi Z. Results showed that 7 compounds made up the major contributions of antioxidant activity in C. tinctoria, including okanin, isookanin, marein, flavanomarein, 5,7,3′,5′‐tetrahydroxyflavanone‐7‐O‐glucoside, 3,5‐dicaffeoylquinic acid, and chlorogenic acid. This site needs JavaScript to work properly. Coreopsis tinctoria, commonly known as goldenwave, calliopsis, golden tickseed, or plains coreopsis, is a flowering annual in the aster family. doi: 10.1016/j.diabres.2017.04.010. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Chian CW, Lee YS, Lee YJ, Chen YH, Wang CP, Lee WC, Lee HJ. 2019 Dec 30;21(1):263. doi: 10.3390/ijms21010263. Get the latest public health information from CDC: https://www.coronavirus.gov. doi: 10.1042/BSR20192384. is an angel on earth for the treatment of diseases, Pear herbal tea as well as preparation method and application thereof, Preparation method of ginger and jujube granule, Bee honey and its use in beautifying cosmetics, August melon and fragile blueberry fruit mixed type fruit wine, Health care tea prepared by using narrow leaves and tender branches of wood of shinyleaf yellowhorn, Food­additive composition containing dendropanax morbifera, Technique of extracting acitve ingredient from roots, stems and leaves from artichoke and application, Herb medicine mixture extracts having antifungal, antiacne, skin calming, moisturizing and sebum controlling activities, Natural health fruit wine and preparation method thereof, Pharmaceutical Composition for Treating or Preventing Diabetes Mellitus Containing an Extract of Chinese Herb as an Effective Ingredient, Entry into force of request for substantive examination, Rejection of a patent application after its publication, Rejection of invention patent application after publication. Epub 2020 Sep 17. Coreopsis tinctoria Nutt has various medical and functional properties and its flower is widely used as health-care tea to decrease blood glucose and to lower blood lipids. of Macau, Macao, China. Note: Values were expressed as the mean ± SD. It is consumed as a herbal tea by local Uyghur people to treat high blood pressure and diarrhea. Clin Exp Nephrol. The anti-inflammatory and antifibrotic effects of Coreopsis tinctoria Nutt on high-glucose-fat diet and streptozotocin-induced diabetic renal damage in rats. In recent years, Coreopsis tinctoria has become a popular herbal tea material in the functional food market because of its remarkable pharmacological activities. AC and marein ameliorated fibrotic markers by regulating NF-κB signaling.

Background. A HG-induced barrier dysfunction model in rat mesangial cells (HBZY-1) was established. Note: Values were expressed as the mean ± SD. PLoS One.

Here we aim to elucidate the protective mechanism of AC and marein, the main ingredient in Coreopsis tinctoria on renal fibrosis and inflammation in vitro under high glucose (HG) conditions. Mechanisms of Herbal Nephroprotection in diabetes mellitus. HBZY-1 cells were pretreated with AC and marein for 2 h, and then stimulated with PDTC, an NF-κB inhibitor followed by NG or HG exposure for 24 h. Equal amounts of lysate were subjected to western blotting analysis to determine NF-κB P-65 and MCP-1. These results indicated that AC and marein may delay the progression of DN, at least in part, by suppressing HG-induced renal inflammation and fibrosis. NIH

HBZY-1 cells were…, NLM The authors declare that they have no competing interests. and you may need to create a new Wiley Online Library account.

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